In Vivo and Ex Vivo Preclinical Studies

Expertise from hundreds of preclinical studies to evaluate your product

preclinical evaluations of in vivo of immunogenicity and efficacyABL has been performing key large and small animal studies for government and commercial clients for over 30 years.  We have a wealth of experience and capabilities to help clients answer their research questions while aiding with candidate selection and testing.  ABL’s scientists have used their knowledge of immunology, virology and animal models to develop numerous disease models to successfully evaluate the efficacy of infectious disease vaccines and therapeutics, as well as immunotherapies for noninfectious diseases, such as cancer.

ABL has pioneered the development of several breakthrough innovations in preclinical studies, including recent examples below:

  • Mucosal infection via repeated low-dose challenge
  • Administration of novel therapeutics, including microbicides and vaccines
  • Collection and processing of mucosal and gut samples, including lymphocyte isolation and analysis
  • Ex vivo infection of tissue explants

These advancements in the field are helping many vaccine, therapeutic and medical countermeasure programs progress to the clinic.

While ABL has an extensive array of assay platforms to evaluate therapeutic and vaccine candidates, we supplement our laboratory service offerings through our network of in vivo service partners. ABL scientists and project managers work with our partners to design, plan and execute preclinical programs, while providing a single point of contact to the client. Examples of programs ABL runs include:

  • Efficacy studies
  • Immunogenicity studies
  • PK/PD and toxicology
  • Biodistribution
  • GLP and non-GLP studies
  • ABSL-2, ABSL-3 and select agent challenge studies

ABL possesses experience managing studies across a wide variety of species, including the following:

  • Large animals: nonhuman primates, domestic animals, goats and sheep.
  • Small animals:  mice, rats, guinea pigs, rabbits, and ferrets.

ABL’s in vivo partners operate facilities that are USDA-registered and accredited by the American Association for the Accreditation of Laboratory Animal Care International (AAALAC), an association widely recognized for its standards of excellence in laboratory animal care.