ABL partners with our clients to develop and optimize the upstream culture and harvest conditions necessary to deliver high yields of a stable therapeutic or vaccine.  ABL will pull upon past experience, and a knowledge of best practices in the field, to deliver a process that meets the necessary production, quality, and regulatory requirements.

ABL’s development goal is to maximize the use of animal-origin-free media and supplements that are commercially available and have a proven track record with regulatory agencies. 

All development studies are approved by the client prior to initiation.  Upon study completion, ABL provides a detailed report explaining the technical approach conducted along with the final process description and results.

Services
Media evaluation and optimization
Feeding strategies for fed-batch bioreactor and fermentor operations
Identification and optimization of process parameters, i.e. viability, cell densities, temperature shift, pH
Process scale-up
Cost of goods analysis

Capabilities
Benchtop fermentors and bioreactors
Wave platform bioreactors
Small-scale technologies for adherent cultures (i.e. roller bottles, cell factories,etc.)

Experience
Recombinant proteins
Antibodies
Fusion Proteins
Cytokines
Vaccines
Viral vectors

Project Management