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Animal Models

ABL’s animal facilities are located in Rockville, Maryland.  We currently operate a ~35,000 square-foot Animal Biosafety Level 2/3 (ABSL-2/3) containment area. ABL's animal facility is USDA-registered and is accredited by the American Association for the Accreditation of Laboratory Animal Care International (AAALAC), an association widely recognized for its standards of excellence in laboratory animal care. As an accredited organization, ABL complies with all policies of the "Guide for the Care and Use of Laboratory Animals," DHHS (NIH 85-23), Animal Welfare (DHHS-TN 73-2) the NIH Manual Issuance 4206 and 6000-3-4-58, "Responsibility for Care and Use of Animals CDC/NIH 4th edition”, “Biosafety in Microbiological and Biomedical Laboratories,” and Public Health Service Policy on Humane Care and Use of Laboratory Animals. ABL has a Category 1 assurance from OLAW of the Public Health Service.

ABL has been performing vital non human primate (NHP) studies for government and commercial clients for over 30 years.  We have a wealth of experience and capabilities to help clients answer their research questions and aid with candidate selection.  We regularly perform both small and large client studies and are able to perform the necessary animal manipulations along with a majority of the associated Efficacy and Potency Testing.  All NHPs go through a rigorous prescreening before they arrive at ABL’s location and are tested again during our mandatory 60-day quarantine to ensure the animals meet the requirements.  The testing includes a viral panel (e.g., SIV, SRV, STLV, measles and Herpes B virus) within 30 days prior to shipment to ABL’s animal facility which is performed again during the quarantine period. 

Here are some highlights of our capabilities and experience: 

Preclinical Studies

  • Proof-of-Concept Studies
  • Challenge Studies
  • Efficacy
  • Potency
  • Immunogenicity
  • PK/PD and Toxicology
  • Biodistribution
  • Optimization of delivery methods
  • Clinical and anatomical pathology evaluations

Sample Processing and Analysis

  • Histopathology
  • Whole blood processing to PBMCs, serum, and plasma
  • Mucosal Tissue processing and cell isolation
  • Viral Load Analysis
  • Immunophenotyping (i.e., CD4 Counts)
  • Cytokine analysis

Capabilities

Routes of Administration Tissue/Sample Collections
Systemic Blood
Intranasal Sera
Subcutaneous Plasma
Intramuscular Bone Marrow
Intradermal Mucosal-Nasal, Vagina, Rectal, Bronchoalveolar lavages
Intraperitoneal Biopsies
Per Os Peripheral Blood (PBMC)
Intravenous Cerebral Spinal Fluid
Stomach intubation Whole saliva
Electroporation Urine
Gene gun Breast
Biojector Lung
Bacterial colonization Heart
Mucosal Lymph node
Cervicovaginal Spleen
Colorectal Intestine
Liver
Vaginal/rectal pinches

Please contact ABL to help design and implement your animal study needs.

ABL, Inc.
9800 Medical Center Drive
Building D
Rockville, MD, 20850

Toll Free: 800-225-5600
Local: 301-881-5600
Fax: 301-816-5438

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For information about Catalog Products, please call: 301-816-5200 or email